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Taking certain opioids while on commonly prescribed antidepressants may increase the risk of overdose

  • Written by Ismaeel Yunusa, Assistant Professor of Clinical Pharmacy and Outcomes Sciences, University of South Carolina
Taking certain opioids while on commonly prescribed antidepressants may increase the risk of overdoseCertain SSRIs can inhibit the breakdown of opioids in the body.Glasshouse Images/The Image Bank via Getty Images

Taking oxycodone at the same time as certain selective serotonin reuptake inhibitors (SSRIs), a commonly prescribed class of antidepressant, can increase the risk of opioid overdose, according to a study my colleagues and I published.

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