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  • Written by Christopher Damman, Associate Professor of Gastroenterology, School of Medicine, University of Washington
Athletes looking for a competitive edge may find it within their gut microbiome

When milliseconds can mean the difference between silver and gold, endurance athletes in sports like marathon running, cycling, rowing and swimming optimize every aspect of their physiology for a competitive edge.

Many of these efforts result in enhancing the performance of mitochondria[1], the tiny but mighty energy-generating powerhouses within your cells. Carefully calibrated doses of exercise[2] combined with beneficial stress – altitude[3], cold[4] and heat[5] – and optimized recovery in the form of nutrition[6], meditation[7] and sleep[8], positively affect the number and health of mitochondria[9] in the cells of your muscles[10], heart[11] and brain[12].

But there is another aspect of endurance training that may have largely been overlooked by athletes and trainers – the role of the gut microbiome[13] in optimizing your mitochondrial health and fitness.

I am a physician-scientist and gastroenterologist[14] who has studied how food affects the gut microbiome’s role in health and disease for over 20 years. While research evaluating food’s effects on the microbiome and mitochondria[15] is improving our understanding of conditions like obesity[16], cancer[17], rheumatoid arthritis[18] and Alzheimer’s disease[19], it might also help athletes achieve new levels of performance through innovative approaches to nutrition.

Of microbiomes and mitochondria

The gut microbiome, a hidden factory of highly collaborative microorganisms in your intestines, ensures that your metabolism, immune system and brain run smoothly. Some researchers liken it to another organ[20] that senses nutritional inputs, manufactures signaling molecules and prepares your body to respond appropriately.

Research has shown that endurance athletes have different gut microbiomes compared with the general population. Their microbiome’s composition[21] and function, like increased production of a short-chain fatty acid called butyrate[22], are associated with increased VO2 max, a fitness benchmark that measures your ability to consume oxygen during intense exercise. One organism in particular, Veillonella[23] is found in some elite runners and may help raise lactate threshold, a fitness metric closely linked to mitochondrial function and how long an athlete is able to sustain intense effort.

Mitochondria are more than just the powerhouses of the cell.

A healthy microbiome communicates with the mitochondria[24], the tiny structures within your cells that convert calories into the raw cellular energy required for muscle contraction and other essential functions. It does this by transforming undigested food components of a healthy diet[25] – like fiber[26], polyunsaturated fats[27] and polyphenols[28] – into molecules that increase the number and health of your mitochondria[29].

Some of these metabolites – butyrate[30], conjugated linoleic acid[31] and urolithin A[32] among them – have been shown to specifically improve muscle strength and endurance. Combining exercise with diets high in fiber, polyphenols – a chemical compound from plants – and healthy fats may thus augment mitochondrial fitness[33] and improve exercise performance.

Nutritional gaffes and gaps

Healthy diets are critical for microbiome and mitochondrial health. Conversely, ultra-processed diets have been linked to conditions ranging from obesity[34] and cancer[35] to autoimmune disease[36] and Alzheimer’s disease[37]. Some people believe athletes are protected from the adverse health effects of ultra-processed diets[38] due to the beneficial effects of exercise[39]. While this may partially be true, it’s important to consider other factors in diet beyond just the calories burned.

Additives[40] used to improve the taste and appearance of food, like emulsifiers[41], can negatively affect the gut microbiome, compromising the gut barrier[42] and causing systemic inflammation[43], an unhealthy state linked to metabolic disease[44], cancer[45], autoimmune conditions[46] and neurodegenerative diseases[47]. Ultra-processed foods have also removed key factors[48] like fiber, polyphenols and healthy fats found in whole foods that support gut health and signal to the mitochondria that there are calories to be metabolized.

Cyclist eating protein bar, looking out at the road
Protein bars and sports drinks are meant to be complements to a healthy diet. ArtistGNDphotography/E+ via Getty Images[49]

The drinks, shakes, bars and gels used for endurance sports are processed foods[50] formulated to provide concentrated and accessible energy during intense exercise. While unhealthy in other contexts, they can be key for enhancing performance[51] during long endurance events when your body depletes its own version of accessible carbohydrates called glycogen.

But it’s important to complement these energy supplements with a healthy diet in the recovery hours following exercise. The combination of an unhealthy baseline diet with high-intensity exercise could compromise your gut barrier and increase inflammation. This has been linked to various training-related issues including gastrointestinal upset[52], musculoskeletal injuries[53] and respiratory illnesses[54].

Performance-enhancing microbes

Reintroducing a diet rich in foods that positively affect your microbiome[55] — beans, nuts, seeds, whole grains, fruits and vegetables — during the recovery phase of training can help most people prevent the adverse effects of high-intensity exercise and optimize performance.

However, due to antibiotic misuse[56] and processed diets[57], some people lack key microbes and metabolic machinery needed to convert fibers[58] and polyphenols[59] into useful molecules the body can use. This shortage may explain why some healthy foods and diets might not be beneficial or tolerated by everyone[60].

Jar of yogurt and a wooden spoon on a towel Foods with probiotics, such as yogurt, can be beneficial to your microbiome. annabogush/RooM via Getty Images[61]

Healthy diets might then benefit from reintroducing key microbes into the gastrointestinal tract. Research has shown that specific strains of probiotic bacteria[62] can improve barrier function, reduce systemic inflammation and potentially enhance athletic performance by mitigating the side effects[63] of high-intensity exercise. An alternative approach is to increase consumption of fermented foods[64], such as yogurt and pickled vegetables, which can increase microbiome diversity and decrease systemic inflammation[65].

In some cases, healthy foods might also be complemented by directly providing the body the key metabolites that microbes produce. Research shows that these metabolites – also called postbiotics[66] or exercise mimetics[67] – enhance muscle strength and exercise performance[68]. Some postbiotics also function as prebiotics that fuel the growth of healthy microbes[69] and help restore a damaged microbiome[70].

From research to podium

While the benefits of nutrition targeting your microbiome and mitochondria[71] for general health are increasingly clear, this approach is still in the early days of exploration in endurance sports.

For the occasional exerciser and weekend warrior, whole nutrition strategies[72] that support the microbiome and mitochondria[73] could be quite helpful. These strategies have the potential to improve performance, protect against adverse training effects and prevent chronic health conditions like obesity, cancer and Alzheimer’s disease.

For elite athletes seeking even the smallest of improvements in an already finely tuned training regimen, further research into the gut microbiome’s influence on performance might be invaluable. In a highly competitive field where nothing can be left off the table — or in the cupboard — such interventions might just be the deciding factor between finishing on the podium or off it.

References

  1. ^ performance of mitochondria (doi.org)
  2. ^ doses of exercise (doi.org)
  3. ^ altitude (doi.org)
  4. ^ cold (doi.org)
  5. ^ heat (doi.org)
  6. ^ nutrition (www.ncbi.nlm.nih.gov)
  7. ^ meditation (pubmed.ncbi.nlm.nih.gov)
  8. ^ sleep (doi.org)
  9. ^ mitochondria (doi.org)
  10. ^ muscles (doi.org)
  11. ^ heart (doi.org)
  12. ^ brain (doi.org)
  13. ^ gut microbiome (journals.asm.org)
  14. ^ physician-scientist and gastroenterologist (gastro.uw.edu)
  15. ^ food’s effects on the microbiome and mitochondria (doi.org)
  16. ^ obesity (doi.org)
  17. ^ cancer (doi.org)
  18. ^ rheumatoid arthritis (doi.org)
  19. ^ Alzheimer’s disease (doi.org)
  20. ^ another organ (doi.org)
  21. ^ microbiome’s composition (doi.org)
  22. ^ called butyrate (doi.org)
  23. ^ Veillonella (doi.org)
  24. ^ communicates with the mitochondria (doi.org)
  25. ^ healthy diet (gutbites.org)
  26. ^ fiber (theconversation.com)
  27. ^ polyunsaturated fats (pubmed.ncbi.nlm.nih.gov)
  28. ^ polyphenols (gutbites.org)
  29. ^ number and health of your mitochondria (doi.org)
  30. ^ butyrate (doi.org)
  31. ^ conjugated linoleic acid (doi.org)
  32. ^ urolithin A (doi.org)
  33. ^ augment mitochondrial fitness (gutbites.org)
  34. ^ obesity (doi.org)
  35. ^ cancer (doi.org)
  36. ^ autoimmune disease (doi.org)
  37. ^ Alzheimer’s disease (doi.org)
  38. ^ adverse health effects of ultra-processed diets (doi.org)
  39. ^ beneficial effects of exercise (www.cdc.gov)
  40. ^ Additives (doi.org)
  41. ^ like emulsifiers (doi.org)
  42. ^ gut barrier (doi.org)
  43. ^ systemic inflammation (theconversation.com)
  44. ^ metabolic disease (doi.org)
  45. ^ cancer (doi.org)
  46. ^ autoimmune conditions (doi.org)
  47. ^ neurodegenerative diseases (doi.org)
  48. ^ removed key factors (theconversation.com)
  49. ^ ArtistGNDphotography/E+ via Getty Images (www.gettyimages.com)
  50. ^ processed foods (doi.org)
  51. ^ enhancing performance (doi.org)
  52. ^ gastrointestinal upset (doi.org)
  53. ^ musculoskeletal injuries (doi.org)
  54. ^ respiratory illnesses (doi.org)
  55. ^ foods that positively affect your microbiome (gutbites.org)
  56. ^ antibiotic misuse (doi.org)
  57. ^ processed diets (doi.org)
  58. ^ fibers (doi.org)
  59. ^ polyphenols (doi.org)
  60. ^ tolerated by everyone (gutbites.org)
  61. ^ annabogush/RooM via Getty Images (www.gettyimages.com)
  62. ^ strains of probiotic bacteria (doi.org)
  63. ^ mitigating the side effects (doi.org)
  64. ^ fermented foods (doi.org)
  65. ^ increase microbiome diversity and decrease systemic inflammation (doi.org)
  66. ^ postbiotics (doi.org)
  67. ^ exercise mimetics (doi.org)
  68. ^ muscle strength and exercise performance (doi.org)
  69. ^ fuel the growth of healthy microbes (doi.org)
  70. ^ help restore a damaged microbiome (doi.org)
  71. ^ your microbiome and mitochondria (doi.org)
  72. ^ whole nutrition strategies (gutbites.org)
  73. ^ microbiome and mitochondria (gutbites.org)

Authors: Christopher Damman, Associate Professor of Gastroenterology, School of Medicine, University of Washington

Read more https://theconversation.com/athletes-looking-for-a-competitive-edge-may-find-it-within-their-gut-microbiome-234979

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